Institution name and department

McGill University, Department of Chemistry

Position held





Department of Chemistry, McGill University, 801 Sherbrooke St. W. H3A 0B8 Montreal, Canada



This email address is being protected from spambots. You need JavaScript enabled to view it.

Key words 


Green chemistry

Metal- organic framerworks





Organic synthesis




Areas of Research/Expertise 

 My research group is generally developing new synthetic designs based on solvent- free chemistry, including mechanochemistry, ageing reactivity and thermochemistry. We are developing mechanochemistry in the context of applications (Green chemistry, pharmaceuticals, nanomaterials, metal-organic frameworks, cocrystals, metal and plastics recycling, mechano-enzymatic reactions, biomass chemicals), as well as fundamental understanding. In the context of understanding mechanochemical reactivity, we are pursuing the use and development of in situ monitoring techniques, as well as theoretical modelling approaches based on periodic density functional theory (DFT) modelling, and molecular dynamic (MD).


5 Most representative publications related to mechanochemistry

1.   Julien, P. A.; Germann, L. S.; Titi, H. M.; Etter, M.; Dinnebier, R. E.; Sharma, L.; Baltrusaitis, J.; Friščić, T. “In situ monitoring of mechanochemical synthesis of calcium urea phosphate fertilizer cocrystal reveals highly effective water-based autocatalysis“ Chem. Sci. 2020, 11, 2350-2355.

2.   Friščić, T.; Mottillo, C.; Titi, H. M. “Mechanochemistry for synthesis“ Angew. Chem. Int. Ed. 2020, 59, 1018-1029.

3.   Kaabel, S.; Stein, R. S.; Fomitšenko, M.; Järving, I.; Friščić, T.; Aav, R. “Size-control by anion templating in mechanochemical synthesis of hemicucurbiturils in the solid state“ Angew. Chem. Int. Ed. 2019, 58, 6230-6234.

4.   Hammerer, F.; Loots, L.-A.; Do, J.-L.; Therien, J. P. D.; Nickels, C. W.; Friščić, T.; Auclair, K. ”Solvent-free enzyme activity: quick, high-yielding mechano-enzymatic hydrolysis of cellulose into glucose" Angew. Chem. Int. Ed. 2018, 57, 2621-2624.

5.   Friščić, T.; Halasz, I.; Beldon, P. J.; Belenguer, A. M.; Adams, F.; Kimber, S. A. J.; Honkimäki, V.; Dinnebier, R. E. "Real-time and in situ monitoring of mechanochemical reactions" Nature Chemistry, 2013, 5, 66-73.

5 Most representative publications non-related to Mechanochemistry 

1.   Titi, H. M.; Marrett, J. M.; Dayaker, G.; Arhangelskis, M.; Mottillo, C.; Morris, A. J.; Rachiero, G. P.; Friščić, T.; Rogers, R. D. “Hypergolic Zeolitic Imidazolate Frameworks (ZIFs) as Next-Generation Solid Fuels: Unlocking the Latent Energetic Behavior of ZIFs“ Science Adv. 2019, 5, eaav9044. DOI: 10.1126/sciadv.aav9044

2.   Lisac, K.; Topić, F.; Arhangelskis, M.; Cepić, S.; Julien, P. A.; Nickels, C. W.; Morris, A. J.; Friščić, T.; Cinčić, D. ”Halogen bonds to phosphorus, arsenic and antimony" Nature Commun. 2019, 10:61

3.   Huskić, I.; Pekov, I.; Krivovichev, S.; Friščić, T. "Minerals with Metal-Organic Framework Structures" Science Adv. 2016, 2, e1600621 DOI: 10.1126/sciadv.1600621

4.   Bushuyev, O. S.; Corkery, T. C.; Barrett, C. J.; Friščić, T. "Photo-mechanical






azobenzene co-crystals and in situ X-ray diffraction study of their optically-induced crystal-to-crystal isomerization" Chem. Sci. 2014, 5, 3158-3164.

5.  Cliffe, M. J. C.; Mottillo, C.; Stein, R. S.; Bučar, D.-K.; Friščić, T. "Accelerated aging: a low energy, solvent-free alternative to solvothermal and mechanochemical synthesis of metal-organic materials" Chem. Sci. 2012, 3, 2495-2500.

Orcid ID/ Google Scholar/ Researchgate/ Scopus profiles

Orcid ID


Google Scholar




Scopus profiles


Twitter/ Linkedin/ Instagram accounts





Instagram accounts


Primary focus in mechanochemical research (enter as bullet points)


Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112