Name

Surname

 

 

 

 

 

Leyssens

Tom

Institution name and department

UCLouvain/IMCN

Position held

 

Professor

   

Address/Country

Place L. Pasteur 1

1348 Louvain-la-Neuve, Belgium

E-mail

Webpage

This email address is being protected from spambots. You need JavaScript enabled to view it.

www.uclouvain.Be/leyssens-group

Key words

 

·         Co-crystal

·         polymorphism

   

·         pharmaceutical

·         API

   

·         crystallization

 

   

 Areas of Research/Expertise 

 My main area of research orients towards multi-component crystal structures and the applications thereof. I work in the field of pharmaceutically active compounds. We look into developing resolution processes, purification/separation processes, …

Recently we try to tap into the mechochemical potential of multi-component systems.

5 Most representative publications related to mechanochemistry 

 1.     Shemchuk, O.; Song, L.; Robeyns, K.; Braga, D.; Grepioni, F.;  Leyssens, T. Chem. Comm. 2018,

54  (77),  10890-10892.  Solid-state  Chiral  resolution  mediated  by  stoichiometry:  crystallizing etiracetam with ZnCl2. DOI 10.1039/C8CC06199H

2.       Springuel, G.; Norberg, B. ; Robeyns, K. ; Wouters, J. ; Leyssens, T. Cryst. Growth Des. 2012, 12, 475-

484. Advances  in  pharmaceutical co-crystal screening: Effective co-crystal screening  through structural resemblance. DOI 10.1021/cg201291k

3.       George, F. ; Tumanov, N. ; Norberg, B. ; Robeyns, K. ; Filinchuk, Y.; Wouters, J.; Leyssens, T. Cryst. Growth  Des.  2014,  14,  2880-2892.  Does  chirality  influence  the  tendency  toward  cocrystal formation. doi/10.1021/cg500181t

4.       Springuel, G.; Robeyns, K. ; Norberg, B.; Wouters, J. ; Leyssens, T. Cryst. Growth Des. 2014, 14, 3996-4004. Cocrystal formation between chiral compounds: how cocrystals differ from salts  doi/10.1021/cg500588t

5.       Carletta, A. ; Buol, X. ; Leyssens, T. ; Champagne, B. ; Wouters, J. J. Phys. Chem. C. 2016, 120, 10001- 10008. Polymorphic and isomorphic cocrystals of N-alicylidene-3-aminopyridine with dicarboxylic acids: tuning of solid-state photo- and thermochromism. doi/10.1021/acs.jpcc.6b02734

 

5 Most representative publications non-related to Mechanochemistry 

1. Harmsen, B.; Leyssens, T. Cryst. Growth Des. 2018, 18, 3654-3660. Enabling enantiopurity: combining racemization and dual-drug co-crystal resolution. DOI /10.1021/acs.cgd.8b00438

 

2.     Shemchuk, O.; Song, L.; Robeyns, K.; Braga, D.; Grepioni, F.;  Leyssens, T. Chem. Comm. 2018,

54  (77),  10890-10892.  Solid-state  Chiral  resolution  mediated  by  stoichiometry:  crystallizing etiracetam with ZnCl2. DOI 10.1039/C8CC06199H

 

3. Leyssens, T.; ter Horst, J.H. in Multi-component Crystals: Synthesis, Concepts, Function De Gruyter, p. 205-236. Solution co-crystallization and its applications. ISBN 978-3-11-046495-5

 

4. Leyssens, T.; Springuel, G.; Montis, R. ; Candoni, N. ; Veesler, S. Cryst. Growth Des. 2012, 12, 1520- 1530. Importance of solvent selection for stoichiometrically diverse cocrystal systems.  doi/10.1021/cg201581z

Orcid ID/ Google Scholar/ Researchgate/ Scopus profiles

Orcid ID

/

Google Scholar

https://scholar.google.be/citations?user=0bIeRGcAAAAJ&hl=nl

Researchgate

/

Scopus profiles

https://www.scopus.com/authid/detail.uri?authorId=9535303000

Twitter/ Linkedin/ Instagram accounts

Twitter/

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Linkedin

Tom Leyssens

Instagram accounts

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Primary focus in mechanochemical research 

-       Contacts with mechnochemical community

-       Expanding research and in particular focusing on API

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Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

COST Overview

COST


EU COST is supported by the EU Framework Programme Horizon 2020.

 

 

COST Action CA18112

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