Institution name and department

Barry University Department of Physical Sciences

Position held





11300 NE 2nd Ave, Miami FL 33180/USA



This email address is being protected from spambots. You need JavaScript enabled to view it. sciences/faculty/hamilton.html

Key words


·         porphyrins

·         acid-catalyzed


·         ball-mill

·         aromatization


·         two-step




Areas of Research/Expertise 

Consisting of only undergraduates, the Hamilton research group is interested in exploring greener methods of chemical synthesis, especially for porphyrins. Having shown the possibility of obtaining symmetrical, tetra-substituted porphyrins using simple starting materials through mechanochemistry, we are now investigating mechanochemical synthesis of di-substituted porphyrins, and those having very bulky substituents. We are also developing ways of teaching green chemistry using mechanochemical methods in undergraduate teaching labs. Another area of interest is metal-organic assemblies involving porphyrins as ligands.

5 Most representative publications related to mechanochemistry 


1.      “Extending mechanochemical porphyrin synthesis to bulkier aromatics: tetramesitylporphyrin’ Su, Q.; Hamilton, T. D. Beilstein J. Org. Chem. 2019, 15, 1149–1153. doi:10.3762/bjoc.15.111

2.      “Two-step Mechanochemical Synthesis of Porphyrins” Shy, H.; Mackin, P.; Orvieto, A. S.; Gharbharan, D.; Peterson, G. R.; Bampos, N.; Hamilton, T. D. Faraday Discuss. 2014, 170, 59-69. 10.1039/C3FD00140G

5 Most representative publications non-related to Mechanochemistry 

1.      “A metal-organic framework with three cavities based on three-coloured square tiling derived from a cyclobutane constructed in the solid state” Hamilton, T. D.; Bucar, D.-K.; MacGillivray, L. R. New J. Chem. 2010, 34, 2400-2402.  10.1039/C0NJ00367K

2.      “Engineering New Metal-Organic Frameworks Built from Flexible Tetrapyridines Coordinated to Cu(II) and Cu(I)" Ryan, P.; Lescop, C.; Laliberte, D.; Hamilton, T.; Maris, T.; Wuest, J. Inorg. Chem. 2009, 48, 2793-2807.

3.      “Onion-Shell Metal-Organic Polyhedra (MOPs): A General Approach to Decorate the Exteriors of MOPs Using Principles of Supramolecular Chemistry”

T. D. Hamilton, G. S. Papaefstathiou, T. Friščić, D.-K. Bučar, and L. R. MacGillivray. J. Am. Chem. Soc. 2008, 130, 14366-14367.

4.      ”Coding a coordination-driven self-assembly via a hydrogen-bond-directed solid- state synthesis: An unexpected chiral capsule” T. D. Hamilton, D.-K. Bucar, and L. R. MacGillivray. Chem. Commun. 2007, 1603-1604. 10.1039/B700748E

5.      “A Polyhedral Host Constructed Using a Linear Template” T. D. Hamilton, G. S. Papaefstathiou and L. R. MacGillivray. J. Am. Chem. Soc. 2002, 124, 11606- 11607.

Orcid ID/ Google Scholar/ Researchgate/ Scopus profiles

Orcid ID

Google Scholar




Scopus profiles


Twitter/ Linkedin/ Instagram accounts



Linkedin mechanochem

Instagram accounts


Primary focus in mechanochemical research

·         Porphyrins and related compounds

·         Sustainable synthetic approaches







Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112