Optimization of developed reaction protocols often needs engineering knowledge allowing not only to find optimized reaction conditions but also to provide improved reactor concepts. Mechanochemical syntheses developed in WG1 and mechanistically investigated in W2 will be selected for scale-up by twin screw extrusion (TSE), not only for the gram to multi-kg h-1 production of (pharmaceutical) materials. In the case of APIs, TSE will be also used for improved formulation.

 


Objectives

(i) the environmentally sustainable production of compounds and materials of industrial interest in large scale; (ii) the development of new processing methodologies and the design of new reactors to allow the industrial scale-up of mechanochemical processes and (in collaboration with WG2); (iii) Provide general guidelines for the scale-up of mechanochemical reactions in general and specifically for mechanochemistry in ball mills for industrial relevant products. This includes an assessment of several parameters and in special cases also the development of test equipment at mini- and / or pilot plant scale; iv) Connect academia to the market and industry through the involvement of entrepreneurs, industrialists and investors, to bring on the market the mechanochemically synthetized products; v) Identify the process having the lowest impact for the environment, compared to currently used manufacturing processes.

 

Milestones

(M7) Life Cycle Analysis (LCA) assessment; (M8) Assessment of the important parameters during the scale- up process; (M9) Development of reactors to perform reactions isothermally at adjustable temperature levels to overcome the inhomogeneous and non-stationary temperature behaviour during the mechanochemistry reactions; (M10) Evaluation of the environmental impact and energy consumption for large scale manufacturing by twin screw extrusion of one or two (pharmaceutical) materials, to help make a decision compared to how the product(s) are usually manufactured.

 

Deliverables

(i) Prototypes of reactors for: scale-up process, in situ monitoring, temperature control and guidelines and protocols for scale up process; (ii) For one or two (pharmaceutical) materials, provide Good Manufacturing Practice (GMP)-certification for large scale manufacturing by TSE, complemented by LCA-based labels. The objective on the harmonization on the nomenclature is common to all WGs, and it will be pursued by a strong collaboration among the participants of this COST action. During the final meeting a report summarizing the guidelines for the mechanochemistry reaction (nomenclature, good laboratory practice, critical parameters, etc.) will be presented to the community.


WG3 members List

Name Surname     Ahmad B. Albadarin Institution name and department University of Limerick – Chemical Sciences Department Position ...
Name Surname     ...
Name Surname   Allan Niidu Institution name and department TalTech, Virumaa College Position held   Assistant Professor ...
Name Surname   Allan ...
  address   mail   +...   @... activities
  address   mail   +...   @... ...
Name Surname   Dario Braga Institution name and department Dept of Chemistry Univ of Bologna Position held   Full ...
Name Surname   Dario ...
Name Surname             Deborah Crawford Institution name and department School of Chemistry and Biosciences University of ...
Name Surname           ...
  Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253) c/o 8, Rue de l’Ecole Normale34296 Montpellier, Cedex 5 (France)   evelina.colacino@umontpellier.fr   ...
  Université de Montpellier & Institut ...
Name Surname     Gábor Mucsi Institution name and department Univesrity of Miskolc, Faculty of Earth Science and Engineering ...
Name Surname     ...
  address   mail   +...   @... activities
  address   mail   +...   @... ...
Name Surname   Giancarlo Cravotto Institution name and department University of Turin – Dept. of Drug Science and Technology Position ...
Name Surname   Giancarlo ...
Name Surname           Ingrid Relou Institution name and department Atalanta Business Development Position held   ...
Name Surname           ...
Name Surname       Jose Villoria de la Mano Institution name and department Johnson Matthey Technology Centre Position held ...
Name Surname       ...
Name Surname   Kiril Lisichkov Institution name and department University Ss. Cyril and Methodius, Faculty of Technology and Metallurgy in ...
Name Surname   Kiril ...
Name Surname   Konstantin Kovler Institution name and department Technion – Israel Institute of Technology Position held   ...
Name Surname   Konstantin ...
Name Surname       Krishna K Damodaran Institution name and department University of Icleand, Department of Chemistry Position ...
Name Surname       ...
Name Surname       Ladislav Čelko Institution name and department Brno University of Technology, Central European Institute of Technology ...
Name Surname       ...
Name Surname   Pietro Rando Institution name and department CRB Benelux BV Position held   R&D Manager     ...
Name Surname   Pietro ...
Name Surname             Sabrina Spatari Institution name and department Technion – Israel Institute of Technology ...
Name Surname           ...
Name Surname           Silvester Bolka Institution name and department FTPO, Centre for Cooperation with Industry ...
Name Surname           ...
Name Surname             Stuart James Institution name and department Queen’s University Belfast, School Of Chemistry and ...
Name Surname           ...
Name Surname   VANJA ASANOVIC Institution name and department University of Montenegro, Faculty of Metallurgy and Technology Position ...
Name Surname   VANJA ...

Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

COST Overview

COST


EU COST is supported by the EU Framework Programme Horizon 2020.

 

 

COST Action CA18112

Top