The network, which had set up this Action, comprised of research groups belonging to 20 different COST Member Countries – with 65% of COST Inclusiveness Target Countries (ITCs), 1 COST Near Neighbour Country (NNC) and 5 COST International Partner Countries (IPC). The participants from the international partners (COST International Partners Countries) are scientists with a strong background and knowledge in mechanochemistry having provided milestones, breakthrough and strong advancement in the field. It is worth noting that some of them have been formed in Europe and they continue to share their expertise with their former collaborators in the COST Member Countries, maintaining a strong link to their European roots.
All the participants (from Cost Member Countries and ITCs, NNC and IPC) are already actively working in the field of mechanochemistry in complementary areas of expertise. They constitute already a whole entity built to treat scientifically and technically the topic of mechanochemistry applied to organic synthesis and scale-up with different competencies and cultural inputs.
COST members are distributed among sectors of:
Their affiliations are from:
The initial network has 44% female partners – with the aim of 50% to respect gender balance, with both men and women having equal opportunities in all activities (including management, promoting excellence, research, networking and scientific integration). The initial consortium has already the critical mass, expertise and geographical distribution needed for addressing the challenge and objectives. 20 Early Career Investigators were involved (almost 30% of the proposers) but this number will increase once the Action is launched with the opportunity of recruiting other qualified participants (also to reinforce specialists in Process and Chemical Engineering), to address answers for specific problems not possible to be solved within the initial network. The Action has gathered groups dedicated to the development of methodology in organic, organometallic synthesis and crystal engineering, solvent-free preparation of advanced porous materials, providing technological solutions for in situ and real time reaction monitoring, mechanistic investigations of mechanochemical reactions, theoretical calculations, and structural determination by spectroscopic techniques. The network had gathered 2 experts from 2 large companies and 6 experts from Small to Medium Enterprises (SMEs) devoted to crystal engineering for the pharmaceutical industry. The participation to the network of a ‘Big Skin Care Group’, which is a large Company, and a worldwide leader in grinding solutions on industrial scale and six SMEs, strengthen and demonstrates the high socioeconomic impact and positive effect of the Action, indicating that the consortium has already the right skills for the successful achievement of milestones and objectives.
The IPC institutions in this COST Action will welcome collaboration possibilities and will do all what they can to support the Action. The mutual benefit from their participation stems from: (i) Advanced technologies for in-situ monitoring of the reactions; (ii) Experts in crystal engineering and aging problems with crystals formed by ball milling; (iii) Mechanochemical reactivity using purposely build reactors for synthesis and catalytic reactions performed by ball milling; (iv) Expertise in designing and producing large scale equipment for mechanochemistry, to transfer the lab-scale concept to large-scale facilities, including safety assessment, energy costs and risks assessments of failure by a case-to-case study, and crucial studies for maximising the technological applicability at industrial level. The collaboration of researchers to increase the efficiency of mechanochemical devices through the use of Twin Screw Extrusion (TSE) as an alternative approach for the productions of 20 top seller generics and APIs in general will attract the interest of the pharma industry (see paragraph 2.3.1).