Institution name and department

Dipartimento di Chimica “G. Ciamician” Università di Bologna

Position held


Associate porfessor



Via selmi 2

41026 Bologna- Italy



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Key words


·       Crystal engineering

·       polymorphism


·       Coordination polymer based on Cu and Ag



·       Structure determination




Areas of Research/Expertise 

 Utilization of sovent-free reaction to obtain new compounds, in particular, new polymorph for organic molecules or API and new co-crystals

Moreover I'm interested on the synthesis and characterization of new MOF structures with a Cu(I) core.

Structure determination from powder diffraction data


5 Most representative publications related to mechanochemistry 

(1)               Cappuccino, C.; Farinella, F.; Braga, D.; Maini, L. Mechanochemistry, an Easy Technique to Boost the Synthesis of CuI Pyrazine Coordination Polymers. Cryst. Growth Des. 2019, 19 (8), 4395–4403.

(2)                      Maini, L.; Braga, D.; Grepioni, F.; Lampronti, G. I.; Gaglioti, K.; Gobetto, R.; Chierotti, M. R. From Isomorphous to “Anisomorphous” Ionic Co-Crystals of Barbituric Acid upon Dehydration and Return. CrystEngComm 2016, 9, 2950–2967.

(3)                      Grifasi, F.; Chierotti, M. R.; Gaglioti, K.; Gobetto, R.; Maini, L.; Braga, D.; Dichiarante, E.; Curzi, M. Using Salt Cocrystals to Improve the Solubility of Niclosamide. Cryst. Growth Des. 2015, 15 (4), 1939–1948.

(4)                      Maini, L.; Mazzeo, P. P.; Farinella, F.; Fattori, V.; Braga, D. Mechanochemical Preparation of Copper Iodide Clusters of Interest for Luminescent Devices. Faraday Discuss. 2014, 170 (0), 93–107.

(5)                      Chierotti, M. R. M. R.; Ferrero, L.; Garino, N.; Gobetto, R.; Pellegrino, L.; Braga, D.; Grepioni, F.; Maini, L. The Richest Collection of Tautomeric Polymorphs: The Case of 2-Thiobarbituric Acid. Chem. - A Eur. J. 2010, 16 (14), 4347–4358.

5 Most representative publications non-related to Mechanochemistry 

Cappuccino, C.; Catalano, L.; Marin, F.; Dushaq, G.; Raj, G.; Rasras, M.; Rezgui, R.; Zambianchi, M.; Melucci, M.; Naumov, P.; et al. Structure–Mechanical Relationships in Polymorphs of an Organic Semiconductor (C4-NT3N). Cryst. Growth Des. 2020, acs.cgd.9b01281.

Cappuccino, C.; Canola, S.; Montanari, G.; Lopez, S. G.; Toffanin, S.; Melucci, M.; Negri, F.; Maini, L. One Molecule, Four Colors: Discovering the Polymorphs of a Thieno(Bis)Imide Oligomer. Cryst. Growth Des. 2019, 19 (5), 2594–2603.

Zappi, A.; Maini, L.; Galimberti, G.; Caliandro, R.; Melucci, D. Quantifying API Polymorphs in Formulations Using X-Ray Powder Diffraction and Multivariate Standard Addition Method Combined with Net Analyte Signal Analysis. Eur. J. Pharm. Sci. 2019, 130, 36–43.

Cappuccino, C.; Mazzeo, P. P.; Salzillo, T.; Venuti, E.; Giunchi, A.; Della Valle, R. G.; Brillante, A.; Bettini, C.; Melucci, M.; Maini, L. Synergic Approach of X-Ray Powder Diffraction and Raman Spectroscopy for Crystal Structure Determination of 2,3-Thienoimide Capped Oligothiophenes. Phys. Chem. Chem. Phys. 2018, 20 (5), 3630–3636.

Maini, L.; Braga, D.; Farinella, F.; Melotto, E.; Verzini, M.; Brescello, R.; Michieletto, I.; Munari, I. Crystal Forms of Enzalutamide and a Crystal Engineering Route to Drug


Purification. Cryst. Growth Des. 2018.

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Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
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COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112