Institution name and department  

Institute of Chemical Sciences

Faculty of Chemistry

Maria Curie-Sklodowska University

Position held





pl. Marii Curie-Skłodowskiej 2

20-031 Lublin




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Key word


crystal engineering









Areas of Research/Expertise


X-ray crystallography and crystal engineering:


-        X-ray single crystal diffraction studies of small molecule organic and organometallic compounds,

-        molecular structure and intermolecular interactions in the solid state - identification of the molecular binding sites, main supramolecular synthons, the role of weak hydrogen bonds in stabilization of the crystal structure,

-        polymorph screening and preparation of polymorphic samples,

-        thermal stability studies, estimating of thermodynamic stability relationship of polymorphs (DSC, VT PXRD, DFT calculations),

-        mechanochemical preparation of adducts (molecular salts and co-crystals) of hydrazones with polycarboxylic acids,

-        polymorphism of multi-component crystal forms of APIs and salt-cocrystal equilibrium.


Chemical  synthesis:


-        synthesis of hydrazones, amidrazones, 1,2,4-triazoles and their transition metal complexes (a potential antibacterial and/or anticancer drugs)

-        synthesis of lanthanide coordination polymers with heteroaromatic polycarboxylic acids


Most representative publications related to mechanochemistry 

Mazur, L., Materek, I., Bond, A. D., Jones, W. Multicomponent crystal forms of a biologically active hydrazone with some dicarboxylic acids: Salts or cocrystals? Cryst. Growth Des. 2019, 5, 2663.

5 Most representative publications non-related to Mechanochemistry 

1. Mazur, L., Sączewski, J., Jarzembska, K., Szwarc-Karabyka, K., Paprocka, R., Modzelewska-Banachiewicz, B. Synthesis, structural characterization and reactivity of new trisubstituted N1-acylamidrazones: solid state and solution studies. CrystEngComm  2018, 20, 4179.

2. Mazur, L., Kozioł, A. E., Jarzembska, K. N., Paprocka, R., Modzelewska-Banachiewicz, B. Polymorphism and isostructurality of the series of 3-(4 ,5-diaryl-4H-1,2,4-triazole-3-yl)propenoic acid derivatives. Cryst. Growth Des. 2017, 17, 2104.

3. Mazur, L., Jarzembska, K. N., Kaminski, R., Hoser, A. A., Madsen, A. Ø., Pindelska, E., Zielińska-Pisklak, M. Crystal structures and thermodynamic properties of polymorphs and hydrates of selected 2‑pyridinecarboxaldehyde hydrazones. Cryst. Growth Des. 2016, 16, 3101.

4. Mazur, L., Jarzembska, K., Kaminski, R., Wozniak, K., Pindelska, E., Zielinska-Pisklak, M. Substituent and solvent effects on intermolecular interactions in crystals of N-acylhydrazone derivatives: single-crystal X-ray, solid-state NMR and computational studies. Cryst. Growth Des. 2014, 14, 2263.

5. Mazur, L., Modzelewska-Banachiewicz, B., Paprocka, R., Zimecki, M., Wawrzyniak, U. E., Kutkowska, J., Ziółkowska, G. Synthesis, crystal structure and biological activities of a novel amidrazone derivative and its copper(II) complex – A potential antitumor drug. J. Inorg. Biochem. 2012, 114, 55.


Orcid ID/ Google Scholar/ Researchgate/ Scopus profiles

Orcid ID


Google Scholar



Scopus profiles

Twitter/ Linkedin/ Instagram accounts




Instagram accounts


Primary focus in mechanochemical research 


Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112