Name

Surname

Lidia

Tajber

Institution name and department

Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences

Position held

Associate Professor

Address/Country

Trinity College Dublin, College Green, Dublin 2, Ireland.

E-mail

Webpage

This email address is being protected from spambots. You need JavaScript enabled to view it.

https://www.tcd.ie/research/profiles/?profile=ltajber

Key words (up to 5)

·      Pharmaceuticals

·     Hot melt extrusion

·      Amorphous

·      Anti-crystal engineering

·      Ionic liquids

Areas of Research/Expertise (please provide a short write up to 250 words)

My areas of research include the fundamental investigations into pharmaceutical crystalline and non-crystalline materials including multicomponent systems such as salts, cocrystals and ionic liquids for the advancement of pharmaceutical formulations. The emphasis of the research work is to improve physicochemical properties of the active pharmaceutical ingredients, especially solubility and processability, to improve bioavailability of drug substances. Specific areas include solid state transformations and reactions, anti-crystal engineering (ionic liquid and deep eutectic forms) and well as amorphous salts and the amorphous polymeric salt formation. My research activities fit with the national (Irish) policy objectives supporting the development and production of a highly educated and relevant workforce in demand by the pharmaceutical industry. Expertise includes the application of thermal analysis and spectroscopy for the monitoring of solid-state transitions and proton transfer reactions, pharmaceutical processing, such as spray drying, milling and hot melt extrusion and (bio)pharmaceutical testing such solubility, dissolution and permeability assessments.

5 Most representative publications related to mechanochemistry 

(1)     Umerska, A.; Bialek, K.; Zotova, J.; Skotnicki, M.; Tajber, L. Anticrystal Engineering of Ketoprofen and Ester Local Anesthetics: Ionic Liquids or Deep Eutectic Mixtures? Pharmaceutics 2020, 12 (4). https://doi.org/10.3390/pharmaceutics12040368 

(2)     Wojnarowska, Z.; Zotowa, J.; Knapik-Kowalczuk, J.; Tajber, L.; Paluch, M. Effect of Electrostatic Interactions on the Relaxation Dynamics of Pharmaceutical Eutectics. Eur. J. Pharm. Sci. 2019, 134, 93–101. https://doi.org/10.1016/j.ejps.2019.04.014 

(3)     Mesallati, H.; Umerska, A.; Paluch, K. J.; Tajber, L. Amorphous Polymeric Drug Salts as Ionic Solid Dispersion Forms of Ciprofloxacin. Mol. Pharm. 2017, 14 (7), 2209–2223. https://doi.org/10.1021/acs.molpharmaceut.7b00039

(4)     Mesallati, H.; Mugheirbi, N. A.; Tajber, L. Two Faces of Ciprofloxacin: Investigation of Proton Transfer in Solid State Transformations. Cryst. Growth Des. 2016, 16 (11), 6574–6585. https://doi.org/10.1021/acs.cgd.6b01283 

(5)     Paluch, K. J.; McCabe, T.; Müller-Bunz, H.; Corrigan, O. I.; Healy, A. M.; Tajber, L. Formation and Physicochemical Properties of Crystalline and Amorphous Salts with Different Stoichiometries Formed between Ciprofloxacin and Succinic Acid. Mol. Pharm. 2013, 10 (10), 3640–3654. https://doi.org/10.1021/mp400127r 

5 Most representative publications non-related to Mechanochemistry 

(1)      Kozyra, A.; Mugheirbi, N. A.; Paluch, K. J.; Garbacz, G.; Tajber, L. Phase Diagrams of Polymer-Dispersed Liquid Crystal Systems of Itraconazole/Component Immiscibility Induced by Molecular Anisotropy. Mol. Pharm. 2018, 15 (11), 5192–5206. https://doi.org/10.1021/acs.molpharmaceut.8b00724

(2)      McComiskey, K. P. M.; Mugheirbi, N. A.; Stapleton, J.; Tajber, L. In Situ Monitoring of Nanoparticle Formation: Antisolvent Precipitation of Azole Anti-Fungal Drugs. Int. J. Pharm. 2018, 543 (1–2), 201–213. https://doi.org/10.1016/j.ijpharm.2018.03.054

(3)      Mesallati, H.; Tajber, L. Polymer/Amorphous Salt Solid Dispersions of Ciprofloxacin. Pharm. Res. 2017, 34 (11), 2425–2439. https://doi.org/10.1007/s11095-017-2250-z

(4)      Wojnarowska, Z.; Paluch, K. J.; Shoifet, E.; Schick, C.; Tajber, L.; Knapik, J.; Wlodarczyk, P.; Grzybowska, K.; Hensel-Bielowka, S.; Verevkin, S. P.; Paluch M. Molecular Origin of Enhanced Proton Conductivity in Anhydrous Ionic Systems. J. Am. Chem. Soc. 2015, 137 (3), 1157–1164. https://doi.org/10.1021/ja5103458

(5)      Knopp, M. M.; Tajber, L.; Tian, Y.; Olesen, N. E.; Jones, D. S.; Kozyra, A.; Löbmann, K.; Paluch, K.; Brennan, C. M.; Holm, R.; et al. Comparative Study of Different Methods for the Prediction of Drug-Polymer Solubility. Mol. Pharm. 2015, 12 (9), 3408–3419. https://doi.org/10.1021/acs.molpharmaceut.5b00423

Orcid ID/ Google Scholar/ Researchgate/ Scopus profiles

Orcid ID

0000-0003-1544-6796

Google Scholar

https://scholar.google.com/citations?user=xTjbiHEAAAAJ&hl=en

Researchgate

https://www.researchgate.net/profile/Lidia_Tajber

Scopus profiles

Author ID: 8621046300

Twitter/ Linkedin/ Instagram accounts

Twitter/

@LidiaTajber

Linkedin

https://ie.linkedin.com/in/lidiatajber

Instagram accounts

(none)

Primary focus in mechanochemical research