José Carlos


Institution name and department

Universidad Complutense, Madrid

Department of Chemistry in Pharmaceutical Sciences,

Organic and Medicinal Chemistry Unit

Position held


Full professor



School of Pharmacy, Plaza de Ramón y Cajal, sn. 28040 Madrid, Spain



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Key words 


·         Multicomponent reactions

·      Diversity-oriented synthesis


·         Domino reactions

·      Drug discovery


·         Heterocycles



Areas of Research/Expertise


1.    Synthetic methodology: Development of multiple bond-forming reactions, specially multicomponent and domino reactions in the area of heterocyclic chemistry. Application of these reactions to diversity-oriented synthesis in the area of drug discovery.

2.    Medicinal chemistry: Application of multitarget strategies in the areas of neurodegenerative diseases and chemotherapy of neglected infectious diseases (tuberculosis, leishmaniasis, Chagas disease).

3.    Small-molecule theranostics.

5 Most representative publications related to mechanochemistry

1.    M. Leonardi, V. Estévez, M. Villacampa, J. C. Menéndez. Diversity-oriented synthesis of complex pyrrole-based architectures from very simple starting materials. Advanced Synthesis and Catalysis, 2019, 361, 2054-2074. DOI: 10.1002/adsc.201900044.

2.    M. Leonardi, M. Villacampa, J. C. Menéndez. Mechanochemical synthesis of biologically relevant heterocycles, in R. Ballini (Ed.) Green synthetic processes and procedures, Chapter 8. Royal Society of Chemistry, 2019, ISBN 978-1-78801-512-7.

3.    M. Leonardi, M. Villacampa, J. C. Menéndez. Multicomponent mechanochemical synthesis. Chemical Science, 2018, 9, 2042 – 2064, DOI: 10.1039/C7SC05370C.

4.    M. Leonardi, M. Villacampa, J. C. Menéndez. High-speed vibration milling-promoted synthesis of symmetrical frameworks containing two or three pyrrole units. Beilstein Journal of Organic Chemistry, 2017, 13, 1957-1962. (Special issue on Mechanochemistry), DOI:10.3762/bjoc.13.190.

5.    M. Leonardi, M. Villacampa, J. C. Menéndez. Mild and general synthesis of pyrrolo[2,1-a]isoquinolines and related frameworks from pyrrole precursors derived from a mechanochemical multicomponent reaction. Journal of Organic Chemistry, 2017, 82, 2570-2578. DOI: 10.1021/acs.joc.6b02995).

6.    V. Estévez, V. Sridharan, S. Sabaté, M. Villacampa, J. C. Menéndez. Three-component synthesis of pyrrole-related nitrogen heterocycles by a Hantzsch-type process: Comparison between conventional and high-speed vibration milling conditions. Asian Journal of Organic Chemistry, 2016, 5, 652–662, DOI: 10.1002/ajoc.201600061.

7.    V. Estévez, M. Villacampa, J. C. Menéndez. Concise synthesis of atorvastatin lactone under high-speed vibration milling conditions. Organic Chemistry Frontiers, 2014, 1, 458-463. DOI: 10.1039/C4QO00052H.

8.    V. Estévez, M. Villacampa, J. C. Menéndez. Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions. A generalization of the Hantzsch pyrrole synthesis. Chemical Communications, 2013, 49, 591-593. DOI: 10.1039/C2CC38099D.

5 Most representative publications non-related to Mechanochemistry 

1.  B. S. Vachan, M. Karuppasamy, P. Vinoth, S. Vivek Kumar, S. Perumal, V. Sridharan, J. C. Menéndez. Organic transformations in water catalyzed by proline and its derivatives. Advanced Synthesis and Catalysis, 2020, 362, 87-110. DOI: 10.1002/adsc.201900558.

2.  I. Muthukrishnan, V. Sridharan, J. C. Menéndez. Progress in the chemistry of tetrahydroquinolines. Chemical Reviews, 2019, 119, 5057−5191. DOI: 10.1021/acs.chemrev.8b00567.

3.  M. Staderini, M. Piquero, M. A. Abengózar, M. Nachér-Vázquez G. Romanelli, P. López-Alvarado, L. Rivas, M. L. Bolognesi, J. C. Menéndez. Structure-activity relationships and mechanistic studies of novel 4-(polyamino)styrylquinoline derivatives active against Leishmania strains. European Journal of Medicinal Chemistry, 2019, 171, 38-53.

4.  J. F. González, D. Rocchi, T. Tejero, P. Merino, J. C. Menéndez. One-pot synthesis of functionalized carbazoles via a CAN-catalyzed multicomponent process comprising a C-H activation step. Journal of Organic Chemistry, 2017, 82, 7492−7502; DOI: 10.1021/acs.joc.7b01199.

5.  I. Gameiro, P. Michalska, G. Tenti, A. Cores, I. Buendía, A. I. Rojo, N. D. Georgakopoulos, J. M. Hernández-Guijo, M. T. Ramos, G. Wells, M. G. López, A. Cuadrado, J. C. Menéndez, R. León. Discovery of the first dual GSK3β inhibitor / Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease. Scientific Reports, 2017, 7, article nr. 45701, pp. 1-15. DOI: 10.1038/srep45701.

6.  L. De Petrocellis, F. J. Arroyo, P. Orlando, A. Schiano Moriello, R. M. Vitale, P. Amodeo, A. Sánchez, C. Roncero, G. Bianchini, M. A. Martín, P. López-Alvarado, J. C. Menéndez. Tetrahydroisoquinoline-derived urea and 2,5-diketopiperazine derivatives as selective antagonists of the transient receptor potential melastatin 8 (TRPM8) channel receptor and antiprostate cancer agents. Journal of Medicinal Chemistry, 2016, 59, 5661-5683. DOI: 10.1021/acs.jmedchem.5b01448.

7.  G. Bianchini, P. Ribelles, D. Becerra, M. T. Ramos, J. C. Menéndez. Efficient synthesis of 2-acylquinolines based on an aza-vinylogous Povarov reaction. Organic Chemistry Frontiers, 2016, 3, 412–422. DOI: 10.1039/C6QO00037A.

8.  M. Staderini, M. L. Bolognesi, J. C. Menéndez. Lewis acid–catalyzed generation of C-C and C-N bonds on π-deficient heterocyclic substrates. Advanced Synthesis and Catalysis, 2015, 357, 185-195. DOI: 10.1002/adsc.201400674.

9.  G. Tenti, E. Parada, R. León, J. Egea, S. Martínez-Revelles, A. M. Briones, V. Sridharan, M. G. López, M. T. Ramos, J. C. Menéndez. New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury. Journal of Medicinal Chemistry, 2014, 57, 4313-4323. DOI: 10.1021/jm500263v.

10.      P. V. A. Raja, G. Tenti, S. Perumal, J. C. Menéndez. A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction. Chemical Communications, 2014, 50, 12270-12272. DOI: 10.1039/C4CC01791A.

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Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
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COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112