Institution name and department

Novosibirsk State University, Chair of Solid State Chemistry

Position held


Professor, Head of the Chair



Ul. Pirogova, 2, Novosibirsk, 630090 Russian Federation



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Key words 


·       pharmaceuticals

·       polymorphs


·       mechanism

·       co-crystals


·       amorphization



Areas of Research/Expertise

I belong to the scientific school of professor Vladimir Boldyrev, who was the founding president of the International Mechanochemical Asscociation. I am involved in mechanochemical research since many years. My main interest is in elucidating the mechanisms of the mechanochemical transformations. We compare the results of ex situ and in situ experiments, study the role of fluid phases, control polymorphism and polyamorphism. We compare different devices and different protocols of treatment. The effects of impact, shear, pressure, cleavage, milling combined with photoirradiation, cryogenic treatment are studied. We study the role of additives, gasses, humidity, solvents, etc. Mechanochemistry of organic and inorganic compounds is compared.Our main systems of interest are pharmaceuticals, organic and coordination compounds, co-crystals, mechanocomposites, also cleavage of inorganic salts and reactions at the crack tip. High-pressure research is a special topic. We are also deeply involved in studying and controlling mixing.


Most representative publications related to mechanochemistry

1. Boldyreva, E. (2013). Mechanochemistry of inorganic and organic systems: what is similar, what is different?. Chemical Society Reviews, 42(18), 7719-7738;

2. Tumanov, I. A., Achkasov, A. F., Boldyreva, E. V., & Boldyrev, V. V. (2011). Following the products of mechanochemical synthesis step by step. CrystEngComm, 13(7), 2213-2216; DOI: 10.1039/C0CE00869A

3. Michalchuk, A. A., Tumanov, I. A., & Boldyreva, E. V. (2013). Complexities of mechanochemistry: elucidation of processes occurring in mechanical activators via implementation of a simple organic system. CrystEngComm, 15(32), 6403-6412;;

4. Friščić, T., James, S. L., Boldyreva, E. V., Bolm, C., Jones, W., Mack, J., ... & Suslick, K. S. (2015). Highlights from Faraday discussion 170: Challenges and opportunities of modern mechanochemistry, Montreal, Canada, 2014. Chemical Communications, 51(29), 6248-6256; DOI: 10.1039/C5CC90113H

5. Losev, E. A., & Boldyreva, E. V. (2014). The role of a liquid in “dry” co-grinding: a case study of the effect of water on mechanochemical synthesis in a “l-serine–oxalic acid” system. CrystEngComm, 16(19), 3857-3866; DOI: 10.1039/C3CE42321B

6. Michalchuk, A. A., Hope, K. S., Kennedy, S. R., Blanco, M. V., Boldyreva, E. V., & Pulham, C. R. (2018). Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing. Chemical communications, 54(32), 4033-4036; DOI: 10.1039/C8CC02187B

7. Tumanov, I. A., Achkasov, A. F., Myz, S. A., Boldyreva, E. V., & Boldyrev, V. V. (2014, August). Different effect of impact and shear mechanical treatment on mechanochemical cocrystallization of piroxicam and succinic acid. In Doklady Chemistry (Vol. 457, No. 2, pp. 154-159). Pleiades Publishing; DOI: 10.1134/S0012500814080059

8. Michalchuk, A. A., Tumanov, I. A., Konar, S., Kimber, S. A., Pulham, C. R., & Boldyreva, E. V. (2017). Challenges of Mechanochemistry: Is In Situ Real‐Time Quantitative Phase Analysis Always Reliable? A Case Study of Organic Salt Formation. Advanced Science, 4(9), 1700132;

9. Michalchuk, A. A., Tumanov, I. A., & Boldyreva, E. V. (2018). The effect of ball mass on the mechanochemical transformation of a single-component organic system: anhydrous caffeine. Journal of materials science, 53(19), 13380-13389;

10. Michalchuk, A. A., Tumanov, I. A., & Boldyreva, E. V. (2019). Ball size or ball mass–what matters in organic mechanochemical synthesis?. CrystEngComm, 21(13), 2174-2179; DOI: 10.1039/C8CE02109K

11. Boldyrev, V., & Boldyreva, E. (1992). Mechanochemistry of interfaces. In Materials Science Forum (Vol. 88, pp. 711-714). Trans Tech Publications Ltd.;

12. Boldyreva E.V. (2014) Dynamics of Mechanochemical Processes. In: Howard J., Sparkes H., Raithby P., Churakov A. (eds) The Future of Dynamic Structural Science. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht;

13. Tumanov, I. A., Michalchuk, A. A. L., Politov, A. A., Boldyreva, E. V., & Boldyrev, V. V. (2017, January). Inhibition of organic mechanochemical synthesis by water vapor. In Doklady Chemistry (Vol. 472, No. 1, pp. 17-19). Pleiades Publishing;

14. Boldyrev, V. V., Avvakumov, E. G., & Boldyreva, E. V. (2009). Fundamental principles of mechanical activation, mechanosynthesis and mechanochemical technologies. Novosibirsk: SO RAN, 344

15. Boldyreva, E. V., & Boldyrev, V. V. (2010). Mechanochemistry and mechanical activation of solids. Part I. Experimental and Theoretical Studies in Modern Mechanochemistry (Ed. G. Mulas & F. Delogu), 1-19.

16. Tumanov, I. A., Michalchuk, A. A. L., Politov, A. A., Boldyreva, E. V., & Boldyrev, V. V. (2017). Inadvertent liquid assisted grinding: a key to “dry” organic mechano-co-crystallisation?. CrystEngComm, 19(21), 2830-2835; DOI: 10.1039/C7CE00517B

17. Boldyreva, E. (2016). Non-ambient conditions in the investigation and manufacturing of drug forms. Current pharmaceutical design, 22(32), 4981-5000;

18. Drebushchak, T. N., Ogienko, A. A., & Boldyreva, E. V. (2011). ‘Hedvall effect’in cryogrinding of molecular crystals. A case study of a polymorphic transition in chlorpropamide. CrystEngComm, 13(13), 4405-4410; DOI: 10.1039/C1CE05189J

19. Myz, S. A., Shakhtshneider, T. P., Tumanov, N. A., & Boldyreva, E. V. (2012). Preparation and studies of the co-crystals of meloxicam with carboxylic acids. Russian Chemical Bulletin, 61(9), 1798-1809;

20. Boldyreva, Е. М. (2011). Mechanochemistry of organic solids: where are we now?. Frontiers in Mechanochemistry and Mechanical Alloying, 17-20;

Most representative publications non-related to Mechanochemistry

1.              Boldyreva E.V., Boldyrev V.V. (Eds.) Reactivity of Molecular Solids, Molecular Solid State Series, V. 3, Wiley: Chichester, 1999, 328 pp. ISBN 0471999075 9780471999072.

2.              Boldyreva E.V., Dera P. (Eds.) High-Pressure Crystallography. From Novel Experimental Approaches to Applications in Cutting-Edge Technologies, Springer: Dordrecht, 2010, 612 pp./ ISBN 978-90-481-9258-8.

3.              Boldyreva E.V., Zakharov B.A., Rashchenko S.V., Seryotkin Yu.V., Tumanov N.A. Studying Solid-State Transformations Using In Situ X-Ray Diffraction Studies at High-Pressures, Publishing House of Siberian Branch of Russian Academy of Sciences, 2016, Novosibirsk, 156 pp.

4.              M. Rams-Baron, R. Jachowicz, E. Boldyreva, D. Zhou, W. Jamroz, M. Paluch, Amorphous Drugs: Benefits and Challenges, Springer, 2018, 230 p., DOI: 10.1007/978-3-319-72002-9_4.

5.              Naumov P., Chizhik S., Panda M., Nath Naba K., Boldyreva E. Mechanically Responsive Molecular Crystals, ChemRev, 2015, 115 (22), p. 12440-12490.

6.              Chizhik S., Sidelnikov A., Zakharov B., Naumov P.and Boldyreva E., Quantification of Photoinduced Bending of Dynamic Molecular Crystals: From Macroscopic Strain to Kinetic Constants and Activation Energies, Chem. Sci., 2018, 9, 2319-2335,

7.              Zakharov B.A., Goryainov S.V., Boldyreva E.V. Unusual seeding effect in the liquid-assisted high-pressure polymorphism of chlorpropamide, CrystEngComm, 2016, 18 (29), p. 5423-5428. DOI: 10.1039/c6ce00711b

8.              Zakharov B.A., Seryotkin Y.V., Tumanov N.A., Paliwoda D., Hanfland M., Kurnosov A.V., Boldyreva E.V. The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media, RSC Advances, 2016, 6 (95), p. 92629-92637.

9.              Avdeef A., Fuguet E., Llinàs A., Ràfols C., Bosch E., Völgyi G., Verbić T., Boldyreva E., Takács-Novák K.. Equilibrium Solubility Measurement of Ionizable Drugs – Consensus Recommendations for Improving Data Quality, ADMET & DMPK 4(2) 2016, p.117-178.

10.           Matvienko A. A., Maslennikov D. V., Zakharov B. A., Sidelnikov A. A., Chizhik S. A., and Boldyreva E. V., Structural aspects of displacive transformations: what can optical microscopy contribute? Dehydration of Sm2(C2O4)3·10 H2O as a case study, IUCrJ (2017). 4, 588-597.

11.           Zakharov B., Michalchuk A., Morrison C., Boldyreva E., Anisotropic lattice softening near the structural phase transition in the thermosalient crystal 1,2,4,5-tetrabromobenzene, PCCP, 2018, 20, 8523 – 8532, DOI: 10.1039/C7CP08609A

12.           Zakharov, B.A. & Boldyreva, E.V. High pressure: a complementary tool for probing solid state processes, CrystEngComm, 2018, DOI: 10.1039/C8CE01391H

13.           Naumov, P., Sahoo, S. C., Zakharov, B. A., & Boldyreva, E. V. (2013). Dynamic single crystals: kinematic analysis of photoinduced crystal jumping (the photosalient effect). Angewandte Chemie International Edition, 52(38), 9990-9995.

14.           Boldyreva, E. V. (2008). High-pressure diffraction studies of molecular organic solids. A personal view. Acta Crystallographica Section A: Foundations of Crystallography, 64(1), 218-231.  doi:10.1107/S0108767307065786

15.           Boldyreva, E. (2007). High-pressure polymorphs of molecular solids: when are they formed, and when are they not? Some examples of the role of kinetic control. Crystal Growth & Design, 7(9), 1662-1668.

16.           Fucke, K., Myz, S. A., Shakhtshneider, T. P., Boldyreva, E. V., & Griesser, U. J. (2012). How good are the crystallisation methods for co-crystals? A comparative study of piroxicam. New Journal of Chemistry, 36(10), 1969-1977.

17.           Resnati, G., Boldyreva, E., Bombicz, P., & Kawano, M. (2015). Supramolecular interactions in the solid state. IUCrJ, 2(6), 675-690.  doi: 10.1107/S2052252515014608

18.           Boldyreva, E. V. (1997). The concept of the ‘reaction cavity’: A link between solution and solid-state chemistry. Solid State Ionics, 101, 843-849.

19.           Bordallo, H. N., Kolesov, B. A., Boldyreva, E. V., & Juranyi, F. (2007). Different dynamics of chiral and racemic (L-and DL-) serine crystals: Evidenced by incoherent inelastic neutron and Raman scattering. Journal of the American Chemical Society, 129(36), 10984-10985.

20.           Fisch, M., Lanza, A., Boldyreva, E., Macchi, P., & Casati, N. (2015). Kinetic control of high-pressure solid-state phase transitions: A case study on l-serine. The Journal of Physical Chemistry C, 119(32), 18611-18617.

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Primary focus in mechanochemical research 



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  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

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