Institution name and department

Dept of Chemistry Univ of Bologna

Position held


Full Professor



Via F. Selmi 2 – 40126 Bologna - Italy



This email address is being protected from spambots. You need JavaScript enabled to view it.  engineering/en

Key words 


 Chirality in the solid state

 Co-crystals antibacterial



Areas of Research/Expertise 

Utilization of mechanochemical methods (manual grinding and ball milling) to prepare co-crystals and coordination compounds for applications as fertilizers, nutrients and/or inhibitors (of urease, for example)  and antimicrobial agents (in the quest for new antibiotics or enhanced activity of known anticbiotics) and their characterization by solid state methods. Work in collaboration with microbiologists and biochemists to evaluate performance.

5 Most representative publications related to mechanochemistry

Shemchuk O.; Andre V.; Duarte M.T.; Braga D.; Grepioni F., Mechanochemical preparation of molecular and ionic co-crystals of the hormone melatonin,

«CRYSTENGCOMM», 2019, 21, pp. 2949 – 2954

Mazzei L.; Broll V.; Casali L.; Silva M.; Braga D.; Grepioni F.; Baltrusaitis J.; Ciurli S., Multifunctional urea cocrystal with combined ureolysis and nitrification inhibiting

capabilities for enhanced nitrogen management, «ACS SUSTAINABLE CHEMISTRY & ENGINEERING», 2019, 7, pp. 13369 – 13378

Casali, Lucia; Mazzei, Luca; Shemchuk, Oleksii; Honer, Kenneth; Grepioni, Fabrizia*; Ciurli, Stefano; Braga, Dario; Baltrusaitis, Jonas, Smart urea ionic co-crystals with enhanced urease inhibition activity for improved nitrogen cycle management,

«CHEMICAL COMMUNICATIONS», 2018, 54, pp. 7637 – 7640

Dario Braga;Lucia Maini;Fabrizia Grepioni, Mechanochemical preparation of co- crystals, «CHEMICAL SOCIETY REVIEWS», 2013, 42, pp. 7638 – 7648

S. L. James; C. J. Adams; C. Bolm; D. Braga; P. Collier; T. Friscic; F. Grepioni; K. D.

M. Harris; G. Hyett; W. Jones; A. Krebs; J. Mack; L. Maini; A. G. Orpen; I. P. Parkin;

W. C. Shearouse; J. W. Steed; D. C. Waddell;, Mechanochemistry: opportunities for new and cleaner synthesis., «CHEMICAL SOCIETY REVIEWS», 2012, 41, pp. 413 - 447

5 Most representative publications non-related to Mechanochemistry 

1.   Shemchuk O.; Braga D.; Grepioni F., Ionic Cocrystals of Levodopa and Its Biological Precursors l-Tyrosine and l-Phenylalanine with LiCl, «CRYSTAL GROWTH & DESIGN», 2019, 19, pp. 6560 – 6565

2.   Casali L.; Mazzei L.; Shemchuk O.; Sharma L.; Honer K.; Grepioni F.; Ciurli S.; Braga D.; Baltrusaitis J., Novel Dual-Action Plant Fertilizer and Urease Inhibitor: Urea·Catechol Cocrystal. Characterization and Environmental Reactivity, «ACS SUSTAINABLE CHEMISTRY & ENGINEERING», 2019, 7, pp. 2852 – 2859

3.   Dario Braga, Fabrizia Grepioni, Lucia Maini, Simone d'Agostino, From Solid-State Structure and Dynamics to Crystal Engineering, «EUROPEAN JOURNAL OF INORGANIC CHEMISTRY», 2018, 32, pp. 3597 – 3605

4.   Shemchuk, Oleksii; Song, Lixing; Robeyns, Koen; Braga, Dario; Grepioni, Fabrizia*; Leyssens, Tom, Solid-state chiral resolution mediated by stoichiometry: Crystallizing etiracetam with ZnCl2, «CHEMICAL COMMUNICATIONS», 2018, 54, pp. 10890 – 10892

5.   Braga, Dario; Grepioni, Fabrizia; Maini, Lucia; D'Agostino, Simone, Making crystals with a purpose; A journey in crystal engineering at the University of Bologna,

«IUCRJ», 2017, 4, pp. 369 - 379

Orcid ID/ Google Scholar/ Researchgate/ Scopus profiles

Orcid ID

·      0000-0003-4162-4779

Google Scholar




Scopus profiles



Twitter/ Linkedin/ Instagram accounts




Instagram accounts


Primary focus in mechanochemical research 


Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112