Institution name and department

University of Patras, Dept. of Chemistry

Position held


Associate Professor



University of Patras, Rion Campus, North Chemistry building, 2nd floor, GR265 04, Rion, Patras, GREECE



This email address is being protected from spambots. You need JavaScript enabled to view it.  athanassopoulos-constantinos

Key words (up to 5)


·       Synthetic Organic Chemistry

·       Natural Products


·       Synthesis of compounds with medicinal/ pharmaceutical interest




Areas of Research/Expertise 

 ·        Medicinal and synthetic organic chemistry in the fields of anticancer and antimicrobial agents, with special attention in targeting resistant cancer cells and bacteria.

·        The chemical modification of naturally occurring bioactive organic compounds (polyamines, retinoids, psoralens, chloramphenicol, abietane diterpenes etc.) and synthetic drugs aiming to alter their biological profile (enhance or modify their activity and/or improve their selectivity).


We are interested in the implementation of Mecahnochemistry steps in our synthetic procedures and especially for building heterocyclic scaffolds.


5 Most representative publications related to mechanochemistry 


5 Most representative publications non-related to Mechanochemistry

1.   Kalantzi, S.; Athanassopoulos, C. M.; Ruonala, R.;  Helariutta, Y.; Papaioannou, D., General Approach for the Liquid-Phase Fragment Synthesis of Orthogonally Protected Naturally Occurring Polyamines and Applications Thereof. J Org Chem 2019, 84 (23), 15118-15130.

2.   Giannopoulou, P. C.;  Missiri, D. A.;  Kournoutou, G. G.;  Sazakli, E.;  Papadopoulos, G. E.; Papaioannou, D.; Dinos, G. P.; Athanassopoulos,* C. M.; Kalpaxis, D. L., New Chloramphenicol Derivatives from the Viewpoint of Anticancer and Antimicrobial Activity. Antibiotics (Basel) 2019, 8 (1)

3.   Magoulas, G. E.;  Tsigkou, T.; Skondra, L.;  Lamprou, M.;  Tsoukala, P.;  Kokkinogouli, V.; Pantazaka, E.; Papaioannou, D.;  Athanassopoulos,* C. M.; Papadimitriou, E., Synthesis of nοvel artemisinin dimers with polyamine linkers and evaluation of their potential as anticancer agents. Bioorganic and Medicinal Chemistry 2017, 25 (14), 3756-3767.

4.   Sonia Stoica, G. E. M., Antonia I. Antoniou, Sherif Suleiman, Analisse Cassar, Lucienne Gatt, Dionissios Papaioannou, Constantinos M. Athanassopoulos*, Pierre Schembri-Wismayer*, Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents. Bioorganic

& Medicinal Chemistry Letters 2016.

5. Antoniou, A. I.; Pepe, D. A.; Aiello, D.;  Siciliano, C.; Athanassopoulos,* C. M., Chemoselective Protection of Glutathione in the Preparation of Bioconjugates: The Case of Trypanothione Disulfide. The Journal of Organic Chemistry 2016, 81 (10), 4353-4358.

Orcid ID/ Google Scholar/ Researchgate/ Scopus profiles

Orcid ID

Google Scholar



Scopus profiles


Twitter/ Linkedin/ Instagram accounts





Instagram accounts


Primary focus in mechanochemical research 






Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112