Institution name and department

Università degli Studi di Cagliari, Dipartimento di Scienze Chimiche e Geologiche

Position held


Associate Professor



Cittadella Universitaria di Monserrato, SS 554 bivio per Sestu, 09042-Monserrato (CA), Italy



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Key words 



Areas of Research/Expertise 

The diverse experience of Prof. Andrea Porcheddu ranges from the synthesis of chimera molecules possessing complex molecular architecture to environmentally friendlier alternatives for synthesis using the most advanced technologies such as solid-phase synthesis, combinatorial chemistry, green chemistry in eutectic solvents, microwaves, LED irradiate organic synthesis, and mechanochemistry for API preparation. The second field of interest concerns the development of novel Borrowing Hydrogen and Transfer Hydrogenation strategies for making C-N bonds using tertiary amines or alcohols instead of more labile aldehydes. The scientific interests of Prof. Porcheddu are also focused on finding novel and highly efficient non-conventional catalysts (mainly Fe and Cu) and reagents for C-H bond activation, intending to minimize both waste production and energy consumption. Currently, his main scientific interest covers the area of ball-milling chemistry. Is devoted to the study of non-conventional transformations over the field of organic chemistry, which can reduce solvents, by-products, wastes, and they can be defined as environmentally sustainable.

5 Most representative publications related to mechanochemistry 

1.    Porcheddu, A.; Colacino, E.; De Luca, L.; Delogu, F. Metal-Mediated and Metal-Catalyzed Reactions Under Mechanochemical Conditions, ACS Catal. 2020, May 27. .

2.     Colacino, E., Porcheddu, A., Charnay, C., Delogu, F. From enabling technologies to medicinal mechanochemistry: An eco-friendly access to hydantoin-based active pharmaceutical ingredients, Reac. Chem. Eng. 2019, 4, 1179-1188. .

3.    Porcheddu, A., Delogu, F., De Luca, L., Colacino, E. From Lossen Transposition to Solventless "medicinal Mechanochemistry" ACS Sustainable Chem. Eng. 2019, 7, 12044-12051. .

4.    Mocci, R., Murgia, S., De Luca, L., Colacino, E., Delogu, F., Porcheddu, A. Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction Org. Chem. Front. 2018, 5, 531-538.

5.     Mocci, R., De Luca, L., Delogu, F., Porcheddu, A. An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives Adv. Synth. Catal. 2016, 358, 3135-3144.

5 Most representative publications non-related to Mechanochemistry 

1.     Gaspa, S., Porcheddu, A., De Luca, L. Metal-Free Oxidative Cross Esterification of Alcohols via Acyl Chloride Formation Adv. Synth Catal. 2016, 358, 154-158.

2.     Gaspa, S., Porcheddu, A., De Luca, L. Metal-Free Direct Oxidation of Aldehydes to Esters Using TCCA  Org. Lett. 2015, 17, 3666-3669.

3.    Mura, M.G., Rajamäki, S., De Luca, L., Cini, E., Porcheddu, A. A mild and efficient synthesis of substituted quinolines via a cross-dehydrogenative coupling of (Bio)available alcohols and aminoarenes Adv. Synth. Catal. 2015, 357, 576-582. .

4.     Dettori, G., Gaspa, S., Porcheddu, A., De Luca, L. One-pot synthesis of hydroxamic acids from aldehydes and hydroxylamine Adv. Synth Catal. 2014, 356, 2709-2713. .

5.    Mura, M.G., De Luca, L., Taddei, M., Williams, J.M.J., Porcheddu, A. Synthesis of α,β-unsaturated aldehydes based on a one-pot phase-switch dehydrogenative cross-coupling of primary alcohols Org. Lett. 2014, 16, 2586-2589.

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Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
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COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112