Institution name and department

University of Cambridge, Department of Chemistry

Position held


Postdoctoral research associate



Lensfield Road, Cambridge,

CB2 1EW, United Kingdom



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Key words (up to 5)


Areas of Research/Expertise 

- Method development and analysis by HPLC and LCMS

- Rietveld refinement & Scherrer size by PXRD (Collaborator Giulio Lampronti)

- Reversible polymorph interconversion by ball mill grinding

- Solvent equilibrium curves by ball mill grinding

- Ball mill grinding experiments under thermodynamic control

5 Most representative publications related to mechanochemistry 

1.   Belenguer, A. M.; Friscic, T.; Day, G. M.; Sanders, J. K. M., Solid-state dynamic combinatorial chemistry: reversibility and thermodynamic product selection in covalent mechanosynthesis. Chem. Sci. 2011, 2 (4), 696-700. DOI 10.1039/C0SC00533A

2.   Belenguer, A. M.; Lampronti, G. I.; Wales, D. J.; Sanders, J. K. M., Direct Observation of Intermediates in a Thermodynamically Controlled Solid-State Dynamic Covalent Reaction. J. Am. Chem. Soc. 2014, 136 (46), 16156-16166. DOI 10.1021/ja500707z  

3.   Belenguer, A. M.; Lampronti, G. I.; Cruz-Cabeza, A. J.; Hunter, C. A.; Sanders, J. K. M., Solvation and surface effects on polymorph stabilities at the nanoscale. Chem. Sci. 2016, 7 (11), 6617-6627. DOI 10.1039/C6SC03457H

4.   Belenguer, A. M.; Lampronti, G. I.; De Mitri, N.; Driver, M.; Hunter, C. A.; Sanders, J. K. M., Understanding the Influence of Surface Solvation and Structure on Polymorph Stability: A Combined Mechanochemical and Theoretical Approach. J. Am. Chem. Soc. 2018, 140 (49), 17051-17059. DOI 10.1021/jacs.8b08549

5.   Belenguer, A. M.; Lampronti, G. I.; Sanders, J. K. M., Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments. JoVE 2018,  (131), e56824. DOI 10.3791/56824

6.   Belenguer, A. M.; Cruz-Cabeza, A. J.; Lampronti, G. I.; Sanders, J. K. M., On the prevalence of smooth polymorphs at the nanoscale: implications for pharmaceuticals. CrystEngComm 2019, 21 (13), 2203-2211. DOI 10.1039/C8CE02098A

7.   Belenguer, A. M.;; Michalchuk, A. A. L.; Lampronti, G. I.; Sanders, J. K. M., Understanding the unexpected effect of frequency on the kinetics of a covalent reaction under ball-milling conditions. Beilstein J. Org. Chem. 2019, 15, 1226–1235. DOI 10.3762/bjoc.15.120

5 Most representative publications non-related to Mechanochemistry

1.   Widmer, R. N.; Lampronti, G. I.; Anzellini, S.; Gaillac, R.; Farsang, S.; Zhou, C.; Belenguer, A. M.; Wilson, C. W.; Palmer, H.; Kleppe, A. K.; Wharmby, M. T.; Yu, X.; Cohen, S. M.; Telfer, S. G.; Redfern, S. A. T.; Coudert, F.-X.; MacLeod, S. G.; Bennett, T. D., Pressure promoted low-temperature melting of metal–organic frameworks. Nat. Mater. 2019, 18 (4), 370-376. DOI 10.1038/s41563-019-0317-4

2.   Sobczak, S.; Drożdż, W.; Lampronti, G. I.; Belenguer, A. M.; Katrusiak, A.; Stefankiewicz, A. R., Dynamic Covalent Chemistry under High-Pressure:A New Route to Disulfide Metathesis. Chem. Eur. J. 2018, 24 (35), 8769-8773 DOI 10.1002/chem.201801740

3.   Foster, J. A.; Parker, R. M.; Belenguer, A. M.; Kishi, N.; Sutton, S.; Abell, C.; Nitschke, J. R., Differentially Addressable Cavities within Metal–Organic Cage-Cross-Linked Polymeric Hydrogels. J. Am. Chem. Soc. 2015, 137 (30), 9722-9729. DOI 10.1021/jacs.5b05507

4.   Lam, R. T. S.; Belenguer, A.; Roberts, S. L.; Naumann, C.; Jarrosson, T.; Otto, S.; Sanders, J. K. M., Amplification of acetylcholine-binding catenanes from Dynamic Combinatorial Libraries. Science 2005, 308 (5722), 667-669. DOI 10.1126/science.1109999

Orcid ID/ Google Scholar/ Researchgate/ Scopus profiles

Orcid ID


Google Scholar



Ana Belenguer  This email address is being protected from spambots. You need JavaScript enabled to view it.

Scopus profiles


Twitter/ Linkedin/ Instagram accounts





Instagram accounts


Primary focus in mechanochemical research (enter as bullet points)


Contact Info

  • Université de Montpellier & Institut Charles Gerhardt de Montpellier (UMR 5253)
    c/o 8, Rue de l’Ecole Normale
    34296 Montpellier, Cedex 5 (France)

  • +33 (0)4 67 14 43 10
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COST Overview


EU COST is supported by the EU Framework Programme Horizon 2020.



COST Action CA18112